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Wednesday, December 15, 2010

Effects of a Highly Selective Acetylcholine-activated K+ Channel Blocker on Experimental Atrial Fibrillation


  • Taiichi Machida1,  et al.

  • Abstract

    Background—The acetylcholine-activated K+ current (IK,ACh) is a novel candidate for atrial-specific antiarrhythmic therapy. This study investigates the involvement of IK,ACh in atrial fibrillation (AF) using NTC-801, a novel potent and selectiveIK,ACh blocker.
    Conclusions—A selective IK,ACh blockade induced by NTC-801 exerted anti-AF effects mediated by atrial-selective ERP prolongation. These findings suggest thatIK,ACh may be important in the development and maintenance of atrial fibrillation.

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