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Sunday, February 07, 2016

Mitochondria: cell aging

Mayo Clinic researchers extend lifespan by up to 35 percent in mice
February 3, 2016

Aged mice with and without senescent cell clearance (credit: Mayo Clinic) Researchers at Mayo Clinic have discovered that senescent cells — cells that no longer divide and accumulate with age — shorten lifespan by as much as 35 percent in normal mice. Removing these aging cells delays tumor formation, preserves tissue and organ function, and extends lifespan without observed adverse effects, the researchers found, writing Feb. 3 in Nature. … more…

Mitochondria trigger cell aging, researchers discover
February 5, 2016

Components of a typical mitochondrion (credit: Kelvinsong/Creative Commons)
How to rejuvenate or prevent aging in human and mice cells
An international team of scientists led by João Passos at Newcastle University has for the first time shown that mitochondria (the “batteries” of the cells) are major triggers for aging, and eliminating them upon the induction of senescence prevents senescence in the aging mouse liver. As we grow old, cells in our bodies accumulate different types … more…

Delivering genes across the blood-brain barrier to treat brain diseases
February 2, 2016

BBB penetration ft 
Could also help researchers map the brain
Caltech biologists have modified a harmless virus to allow it to enter the adult mouse brain through the bloodstream and deliver genes to cells of the nervous system. The modified virus could lead to novel therapeutics to address diseases such as Alzheimer’s and Huntington’s, help researchers map the brain, and target cells in other organs, according … more…

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