Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study -- Hippisley-Cox et al., 10.1136/bmj.39261.471806.55 -- BMJ

Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study -- Hippisley-Cox et al., 10.1136/bmj.39261.471806.55 -- BMJ: "Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study
Julia Hippisley-Cox, professor of clinical epidemiology and general practice1, Carol Coupland, senior lecturer in medical statistics1, Yana Vinogradova, research fellow in medical statistics1, John Robson, senior lecturer in general practice2, Margaret May, research fellow in medical statistics3, Peter Brindle, research and development strategy lead4
1 Tower Building, University Park, Nottingham NG2 7RD, 2 Centre for Health Sciences, Queen Mary's School of Medicine and Dentistry, London, 3 Department of Social Medicine, University of Bristol, 4 Avon Primary Care Research Collaborative, Bristol Primary Care Trust
Objective To derive a new cardiovascular disease risk score (QRISK) for the United Kingdom and to validate its performance against the established Framingham cardiovascular disease algorithm and a newly developed Scottish score (ASSIGN).
Design Prospective open cohort study using routinely collected data from general practice.
Setting UK practices contributing to the QRESEARCH database.
Participants The derivation cohort consisted of 1.28 million patients, aged 35-74 years, registered at 318 practices between 1 January 1995 and 1 April 2007 and who were free of diabetes and existing cardiovascular disease. The validation cohort consisted of 0.61 million patients from 160 practices. "/.../