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New research at Mayo Clinic in Florida provides insight into how neuronal changes in the brain may lead to some forms of dementia.
The research focuses on the interaction of sortilin, a key player in regulating neuronal viability and function, with TAR DNA–binding protein-43 (TDP-43), a protein that regulates messenger RNA.
Previous research showed that in mouse models TDP-43 binds to sortilin. The current study confirms this and showed, for the first time, that this biological process also occurs in humans, said Mercedes Prudencio, PhD, senior research fellow, who co-led the studies with Leonard Petrucelli, PhD, chair of neuroscience, Mayo Clinic, Jacksonville, Florida.
The Mayo studies also demonstrated that in humans, the sortilin isoform resulting from a lack of TDP-43 affects regulation of progranulin, a neurotrophic growth factor that, when deficient, is linked to cases of frontotemporal lobar degeneration./.../
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