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The Definitive Reading List of the 14 Best Books of 2014 Overall*By: Maria Popova* *From the origin of the universe to the unusual stories behind people’s tattoos, by way of secular spirituality, the hummingbird effect, and Werner Herzog.* I consider my annual best-of reading lists a kind of Old Year’s resolutions in reverse — unlike traditional resolutions, which lay out an aspirational list of priorities for the new year, these represent a look back at the books that proved themselves most worth prioritizing over the setting year. After such reverse-resolution reading lists for the...mais »
Com minhas irmãs (Lia Maria e Maria Helena) visitamos na tarde de ontem nosso primo e tivemos momentos muito agradáveis com a família dele (Rosinha, sua esposa, e três de suas filhas). Registramos o encontro com uma foto. Ele, e seu neto Bruno, planejaram e executaram nosso novo consultório (há 3 anos) no 10 andar do Prime Offices, junto ao Praia de Belas Shopping. Um irmão dele, Walter (mais moço) fez o mesmo há 45 anos atrás, no centro da cidade, onde Valderês e eu atendemos nossos clientes durante 41 anos.
It might be possible to restore lost memories Memories not stored in synapses, neurobiologist finds December 22, 2014 Synapse (credit: Curtis Neveu/Wikimedia Commons) New UCLA research indicates that lost memories can be restored, offering hope for patients in the early stages of Alzheimer’s disease. For decades, most neuroscientists have believed that memories are stored at the synapses — the connections between brain cells, or neurons — which are destroyed by Alzheimer’s disease. The new study provides evidence contradicting the idea that long-term memory is stored at synapses. “Long-...mais »
Color-coding brain cellsDecember 23, 2014 *[+]* Multicolor tracing of newborn neurons. (credit: University of Southampton) University of Southampton neuroscientists have developed a method called “multicolor RGB tracking” to improve our understanding of how the brain works by color-marking individual brain cells in mice allows them to be tracked over space and time.*/.../
Hidden molecular structures in proteins revealed Improved X-ray diffraction software uses statistical methods December 23, 2014 A membrane protein called cysZ, imaged in three dimensions with Phenix software, using data that could not previously be analyzed (credit: Los Alamos National Laboratory) Los Alamos National Lab scientists have developed statistical methods that allow for creating three-dimensional pictures of previously hidden molecular structures in proteins. To view the proteins, researchers produce billions of copies, dissolve them in water, and grow crystals of the protei...mais »
Quantum physics just got less complicated Is "wave-particle duality" simply the quantum "uncertainty principle" in disguise? December 23, 2014 *[+]* Quantum physics says that particles can behave like waves, and vice versa. Researchers have now shown that this “wave-particle duality” is simply the quantum uncertainty principle in disguise (credit: Timothy Yeo/CQT, National University of Singapore) An international team of researchers has proved that two peculiar features of the quantum world previously considered distinct are different manifestations of the same thing. They found that...mais »
Existing drug riluzole may prevent foggy ‘old age’ brain December 24, 2014 [image: When researchers looked at certain neurons (similar to the one shown on top) in rats treated with riluzole, they found an important change in one brain region, the hippocampus: more clusters of so-called spines, receiving connections that extend from the branches of a neuron (bottom). (Credit: Dr. John H. Morrison's lab, The Icahn School of Medicine at Mount Sinai)] New experiments suggest that riluzole, a drug already on the market as a treatment for ALS (Lou Gehrig’s disease), may help prevent the fad...mais »
Optogenetics captures synaptic transmission in live mammalian brain for the first time Could significantly expand our knowledge of connectivity between various types of neurons as a more realistic alternative to in vitro studies December 26, 2014 A reconstruction of a pair of synaptically connected neurons (credit: Aurélie Pala/EPFL) EPFL scientists Aurélie Pala and Carl Petersen have observed and measured synaptic transmission in a live animal for the first time, using optogenetics* to stimulate single neurons in the mouse barrel cortex (which processes sensory information from the m...mais »
Em 30 de junho de 1985, o Centro de Tecnologia da UFSM completou 25 anos de fundação. Organizei, na época, uma exposição comemorativa, no saguão de Centro de Tecnologia, com fotos, documentos e instrumentos. A coleta de documentos e, principalmente, de fotografias exigiu uma laboriosa busca em vários setores da Universidade. Uma das fotos expostas tem grande valor histórico para o Centro de Tecnologia e para a UFSM. Não sei em que dia foi tomada, mas eu a denominei *O “Dia do sim”* No ano de 1958, o Prof. José Mariano da Rocha Filho, então presidente da ASPES-Associação Santa-Mariens...mais »
From the origin of the universe to the unusual stories behind people’s tattoos, by way of secular spirituality, the hummingbird effect, and Werner Herzog.
I consider my annual best-of reading lists a kind of Old Year’s resolutions in reverse — unlike traditional resolutions, which lay out an aspirational list of priorities for the new year, these represent a look back at the books that proved themselves most worth prioritizing over the setting year. After such reverse-resolution reading lists for the best children’s books, art, design, and photography books, science books, philosophy and psychology books, bestbiographies, memoirs, and history books, here comes the annual wholly subjective selection of the fourteen most rewarding books of 2014 overall, in no particular order. (See last year’s selections here.)/.../
Memories not stored in synapses, neurobiologist finds
December 22, 2014
Synapse (credit: Curtis Neveu/Wikimedia Commons)
New UCLA research indicates that lost memories can be restored, offering hope for patients in the early stages of Alzheimer’s disease.
For decades, most neuroscientists have believed that memories are stored at the synapses — the connections between brain cells, or neurons — which are destroyed by Alzheimer’s disease. The new study provides evidence contradicting the idea that long-term memory is stored at synapses.
“Long-term memory is not stored at the synapse,” said David Glanzman, a senior author of the study, and a UCLA professor of integrative biology and physiology and of neurobiology. “The nervous system appears to be able to regenerate lost synaptic connections. If you can restore the synaptic connections, the memory will come back. It won’t be easy, but I believe it’s possible.”
The findings were published recently in eLife, a highly regarded open-access online science journal./.../
Multicolor tracing of newborn neurons. (credit: University of Southampton)
University of Southampton neuroscientists have developed a method called “multicolor RGB tracking” to improve our understanding of how the brain works by color-marking individual brain cells in mice allows them to be tracked over space and time.*/.../
A membrane protein called cysZ, imaged in three dimensions with Phenix software, using data that could not previously be analyzed (credit: Los Alamos National Laboratory)
Los Alamos National Lab scientists have developed statistical methods that allow for creating three-dimensional pictures of previously hidden molecular structures in proteins.
To view the proteins, researchers produce billions of copies, dissolve them in water, and grow crystals of the protein, then shine a beam of X-rays and measure the brightness of each of the thousands of diffracted X-ray spots that are produced./.../
Quantum physics says that particles can behave like waves, and vice versa. Researchers have now shown that this “wave-particle duality” is simply the quantum uncertainty principle in disguise (credit: Timothy Yeo/CQT, National University of Singapore)
An international team of researchers has proved that two peculiar features of the quantum world previously considered distinct are different manifestations of the same thing. They found that “wave-particle duality” is simply the quantum “uncertainty principle” in disguise, reducing two mysteries to one.
The result was published December 19 in Nature Communications and inarXiv (open access).
Patrick Coles, Jedrzej Kaniewski, and Stephanie Wehner made the breakthrough while at the Centre for Quantum Technologies at the National University of Singapore.
“The connection between uncertainty and wave-particle duality comes out very naturally when you consider them as questions about what information you can gain about a system. Our result highlights the power of thinking about physics from the perspective of information,” says Wehner, who is now an Associate Professor at QuTech at the Delft University of Technology in the Netherlands./.../
New experiments suggest that riluzole, a drug already on the market as a treatment for ALS (Lou Gehrig’s disease), may help prevent the fading memory and clouding judgment that comes with advancing age. Researchers at The Rockefeller University and The Icahn School of Medicine at Mount Sinai found they could stop normal, age-related memory loss … more…
Optogenetics captures synaptic transmission in live mammalian brain for the first time
Could significantly expand our knowledge of connectivity between various types of neurons as a more realistic alternative to in vitro studies
December 26, 2014
A reconstruction of a pair of synaptically connected neurons (credit: Aurélie Pala/EPFL)
EPFL scientists Aurélie Pala and Carl Petersen have observed and measured synaptic transmission in a live animal for the first time, using optogenetics* to stimulate single neurons in the mouse barrel cortex (which processes sensory information from the mouse’s whiskers)./.../
Darkness InvisibleThe Hidden Global Costs of Mental Illness By Thomas R. Insel, Pamela Y. Collins, and Steven E. Hyman FROM OUR JANUARY/FEBRUARY 2015 ISSUE The hidden epidemic: in a mental hospital in Shanxi Province, China, October 2010 (Stringer / Courtesy Reuters) Four years ago, a team of scholars from the Harvard School of Public Health and the World Economic Forum prepared a report on the current and future global economic burden of disease. Science and medicine have made tremendous progress in combating infectious diseases during the past five decades, and the group noted that ...mais »
*VISITA DO PRIMO DANIEL BALTAZAR LICHTLER* no dia 16 p.p. deu-nos o prazer de almoçar conosco um primo da Valderês, da linhagem da avó paterna dela. É autor de um livro (Fera em Família) sobre a história de seu pai Augusto Edmundo Lichtler, irmão mais moço da avó Emília Guilhermina Claudina Lichtler que casou com Alberto Guilherme Robinson. Daniel recentemente perdeu um irmão - Gilberto - em cujo culto em homenagem estivemos presentes em São Leopoldo há uma semana, encontrando mais parentes e amigos. .
*Nossa linda nata Júlia, filha do Luiz Eduardo e Maria Cristina e irmã do Eduardo, formou-se no curso secundário no Colégio Marista do Rosário. Prepara-se para a UFRGS em Design.* *Um beijo dos avós Aloyzio e Valderês.*
Breakthrough of the year 2014 [image: This week's cover] - Table of Contents - More Special Issues [image: Science Translational Medicine][image: Science 2014 Breakthrough of the Year]Every year, the editors of *Science *magazine choose one truly amazing scientific achievement as the Breakthrough of the Year. This year, we asked readers to weigh in and tell us what they thought. Was it adding new letters to the DNA alphabet? Developing constellations of tiny satellites? How about the discovery that young blood can reverse aging? Read about the 2014 Breakthrough of the Year and...mais »
Autor: Jéssica Maes Jornalista de 23 anos, acompanha mais seriados do que deveria, é abastecida por doces e livros e, não importa o que digam, sempre acreditou no Snape. Seu corpo é formado por várias células. Disso você já sabia. O que talvez você não saiba é que, para cada célula do seu corpo, existem outros 10 organismos que são essenciais para o desempenho de várias funções que o nosso sistema precisa. Existem cerca de 100 trilhões – vamos repetir: 100 trilhões! – de organismos vivendo sobre ou dentro de você neste momento. Eles entram por sua boca, nariz, ouvidos e por qualquer o...mais »
Could ibuprofen be an anti-aging medicine? December 19, 2014 [image: Ibuprofen extends the lifespan of C. elegans worms: survival curves treated with ibuprofen at 0.1 mM (red) compared to experiment-matched untreated (credit: Chong He et al./PLOS Genetics)]Ibuprofen, a common over-the-counter drug used to relieve pain and fever, could hold the keys to a longer healthier life, according to a study by researchers at the Buck Institute for Research on Aging. Publishing in PLoS Genetics (open access) December 18, scientists showed that regular doses of ibuprofen extended the lifespan of...mais »
Considered one of the most important figures in modern architecture, Brazilian architect Oscar Niemeyer was a pioneer in the use of reinforced concrete. His buildings feature smooth curves that are distinct from those of his more utilitarian contemporaries. Niemeyer's remarkable work in the creation of Brazil's capital, Brasília, included his design for the President's Palace and the cathedral. In 1947, Niemeyer joined a team of architects to design what internationally recognized US building? More...mais »
Brazil, Russia, India, China, and South Africa (BRICS) represent almost half the world's population, and all five national governments recently committed to work nationally, regionally, and globally to ensure that universal health coverage (UHC) is achieved. This analysis reviews national efforts to achieve UHC. With a broad range of health indicators, life expectancy (ranging from 53 years to 73 years), and mortality rate in children younger than 5 years (ranging from 10·3 to 44·6 deaths per 1000 livebirths), a review of progress in each of the BRICS countries shows that each has some way to go before achieving UHC. The BRICS countries show substantial, and often similar, challenges in moving towards UHC. On the basis of a review of each country, the most pressing problems are: raising insufficient public spending; stewarding mixed private and public health systems; ensuring equity; meeting the demands for more human resources; managing changing demographics and disease burdens; and addressing the social determinants of health. Increases in public funding can be used to show how BRICS health ministries could accelerate progress to achieve UHC. Although all the BRICS countries have devoted increased resources to health, the biggest increase has been in China, which was probably facilitated by China's rapid economic growth. However, the BRICS country with the second highest economic growth, India, has had the least improvement in public funding for health. Future research to understand such different levels of prioritisation of the health sector in these countries could be useful. Similarly, the role of strategic purchasing in working with powerful private sectors, the effect of federal structures, and the implications of investment in primary health care as a foundation for UHC could be explored. These issues could serve as the basis on which BRICS countries focus their efforts to share ideas and strategies.
The hidden epidemic: in a mental hospital in Shanxi Province, China, October 2010 (Stringer / Courtesy Reuters)
Four years ago, a team of scholars from the Harvard School of Public Health and the World Economic Forum prepared a report on the current and future global economic burden of disease. Science and medicine have made tremendous progress in combating infectious diseases during the past five decades, and the group noted that noncommunicable diseases, such as heart disease and diabetes, now pose a greater risk than contagious illnesses. In 2010, the report’s authors found, noncommunicable diseases caused 63 percent of all deaths around the world, and 80 percent of those fatalities occurred in countries that the World Bank characterizes as low income or middle income. Noncommunicable diseases are partly rooted in lifestyle and diet, and their emergence as a major risk, especially in the developing world, represents the dark side of the economic advances that have also spurred increased longevity, urbanization, and population growth. The scale of the problem is only going to grow: between 2010 and 2030, the report estimated, chronic noncommunicable diseases will reduce global GDP by $46.7 trillion./.../
Nossa linda nata Júlia, filha do Luiz Eduardo e Maria Cristina e irmã do Eduardo, formou-se no curso secundário no Colégio Marista do Rosário. Prepara-se para a UFRGS em Design. Um beijo dos avós Aloyzio e Valderês.
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