Monday, July 31, 2017

Cholesterol in 2017

Clinicians and patients may find recent studies relevant to decisions about lipid-lowering therapy to be perplexing. There are now, for the first time, 3 evidence-based options to modify atherosclerotic cardiovascular disease risk via lipid-lowering medications. With new information emerging, recent guidelines aging, and decisions needing to be made, this is an opportune time to review lipid-lowering therapy in the age of increasing evidence-based choice. The focus in this Viewpoint is on typical patients, not those with extreme phenotypes.

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Lipid-Lowering Therapy to Reduce Risk of Atherosclerotic Cardiovascular Disease (ASCVD)

Sunday, July 30, 2017

Canaanites/Fenices

Living Descendants of Biblical Canaanites Identified
Via DNA. Genome sequenced from 3,700-year-old remains is found in today's residents
of Lebanon.

Several of the Canaanite individuals sampled in the study had been buried in large clay jars.
PHOTOGRAPH COURTESY DR. CLAUDE DOUMET-SERHAL

By Kristin Romey

PUBLISHED JULY 27, 2017

More than 90 percent of the genetic ancestry of modern Lebanese is derived from ancient Canaanites, according to a paper published today in the American Journal of Human Genetics.

Researchers supported by The Wellcome Trust were able to sequence the Canaanite genome from the remains of five individuals buried in the ancient port city of Sidon (modern Saïda, Lebanon) around 3,700 years ago. The results were compared against the DNA of 99 modern-day Lebanese residents./.../

Kynurenines:

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From stomach ache to depression

Our gut hurts and we feel miserable. Such disparate phenomena are mechanistically connected, but how? Cervenka et al. review the many pathways taken by dietary tryptophan as it is metabolized into kynurenines. These metabolites distribute into homeostatic networks that integrate diverse aspects of mammalian physiology. Depending on physiological context, kynurenines influence health and disease states ranging from intestinal conditions to inflammation to cancer progression. Further, they can mediate the effects of exercise, mood, and neuronal excitability and, ultimately, communicate with the microbiota.

Science, this issue p. eaaf9794/.../

SIR WILLIAM OSLER

Texto sugerido pela AMICOR Maria Inês Reinert Azambuja
SIR WILLIAM OSLER & HIS INSPIRATIONAL WORDS “Wilder Penfield, the eminent Canadian neurosurgeon, said of him: ‘He belongs to medical students of all time, as Lincoln belongs to the common man everywhere, a man who grew to be what he wanted by dint of hard work, and in whose footsteps any undergraduate may dare to hope and dream that he may follow.’ … The life and philosophy of William Osler continues to serve as a standard of excellence and a model for the evolution of the profession and its practitioners.” From The Quotable Osler Sir William Osler, M.D., C.M., 1st Baronet (July 12, 1849 – December 29, 1919) was a Canadian physician. (The "o" in "Osler" is pronounced like the "o" in "go".) He was one of the "Big Four" founding professors at Johns Hopkins Hospital as the first Professor of Medicine and founder of the Medical Service there. (The "Big Four" were William Osler, Professor of Medicine; William Stewart Halsted, Professor of Surgery; Howard A. Kelly, Professor of Gynecology; and William H. Welch, Professor of Pathology.) Osler created the first residency program for specialty training of physicians, and he was the first to bring medical students out of the lecture hall for bedside clinical training. He has been called the "Father of modern medicine." Osler was a pathologist, physician, educator, bibliophile, historian, author, and renowned practical joker.

Read more at: https://forum.facmedicine.com/threads/father-of-medicine-sir-william-osler-and-his-inspirational-words.31013/
Tenho sempre presente uma de suas frases famosas: Medicina é a ciência da incerteza e a arte da probabilidade.

Saturday, July 29, 2017

muscle loss

Stem cells may be the key to staying strong in old age

June 6, 2017

University of Rochester Medical Center researchers have discovered that loss of muscle stem cells is the main driving force behind muscle decline in old age in mice. Their finding challenges the current prevailing theory that age-related muscle decline is primarily caused by loss of motor neurons. Study authors hope to develop a drug or therapy that can slow muscle stem cell loss and muscle decline in the future.

2826 - AMICOR 20

Taste and Obesity

Aloyzio AchuttiemAMICOR - Há 4 horas

Dulled Taste May Prompt More Calories on Path to Obesityby Neuroscience News A new study reveals blocking taste receptors leads people to desire sweeter, higher calorie foods. Researchers believe a dulled sense of taste could increase a person's obesity risk. *Read more of this post* *Neuroscience News* | July 29, 2017 at 10:48 am | Tags: calories, gustatory system, taste system | URL: http://wp.me/p4sXNK-b2Y Comment See all comments

Suicídio familiar

Aloyzio AchuttiemAMICOR - Há 9 horas

Suicídios na mesma família podem ser explicados, em parte, pela genética Divulgação [image: getúlio Vargas em cena do documentário 'imagens do estado novo', de eduardo escorel] Getúlio Vargas (ao microfone) em cena do documentário "Imagens do Estado Novo" *REINALDO JOSÉ LOPES* COLABORAÇÃO PARA A *FOLHA* 29/07/2017 02h02

Proton Pump Inhibitors

Aloyzio AchuttiemAMICOR - Há um dia

Clinical Trend of the Week (July 8-14): Proton Pump Inhibitors Potentially serious consequences associated with a particularly popular drug class resulted in this week's top search term. A study in *BMJ Open* that included more than 6 million people determined that proton-pump inhibitors (PPIs) may be associated with an increased risk for death. PPIs are available by prescription and over-the-counter and are used to treat gastroesophageal reflux and peptic ulcer disease. Use of the medication nearly doubled from 1999-2000 to 2011-2012. The study found that PPI use was associated with... mais »

câncer colorretal

Aloyzio AchuttiemAMICOR - Há um dia

Os testes fecais vão substituir as colonoscopias Publicado por SERMOTeamPT em 27 de Julho de 2017 - 12:39PM EDT De acordo com o Centers for Disease Control and Prevention (CDC), o câncer colorretal é a segunda principal causa de morte por câncer nos Estados Unidos, responsável por 52.000 mortes a cada ano. Nas últimas décadas, colonoscopias foram os testes mais apropriados e recomendados para a pesquisa de cancro do cólon em pacientes com mais de 50 anos, contudo, os custos, a capacidade de invasão e o desconforto não tranquilizam nem motivam as pessoas a realizarem este tipo de... mais »

World Hepatitis day

Aloyzio AchuttiemAMICOR - Há um dia

World Hepatitis Day View this email in your browser Share Tweet Forward *Eliminate hepatitis*

Jeff Bezos

Aloyzio AchuttiemAMICOR - Há um dia

*Philanthropy* *Nossas ideias sobre igualdade, ambiente e saúde urbana também podem ser consideradas como filantrópicas?* *Será que não temos alguma sugestão para dar ao Jeff Bezos?* *A seguir solicitação de ideias por que ontem ficou o homem mais rico do mundo e logo em seguida voltou ao segundo lugar.* View image on Twitter [image: View image on Twitter] Follow Jeff Bezos ✔@JeffBezos Request for ideas…

Philanthropy

Aloyzio AchuttiemAMICOR - Há um dia

Philanthropy Strategies... Solicitação de ideias por quemfoiomaisricodomundoView image on Twitter [image: View image on Twitter] Follow Jeff Bezos ✔@JeffBezos Request for ideas… 3:22 PM - Jun 15, 2017

195 countries access and quality

Aloyzio AchuttiemAMICOR - Há um dia

Volume 390, No. 10091, p231–266, 15 July 2017 Articles Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease Study 2015 [image: show] GBD 2015 Healthcare Access and Quality Collaborators†* Email the author †Collaborators listed at the end of the Article Published: 18 May 2017 Open Access DOI: http://dx.doi.org/10.1016/S0140-6736(17)30818-8 | Open access funded by Bill & Melinda Gates Foundation [image: show]Article Info - Summary - Full Tex... mais »

Biology of Consciousness

Aloyzio AchuttiemAMICOR - Há 2 dias

In Witnessing the Brain’s ‘Aha!’ Moment, Scientists Shed Light on Biology of Consciousness [image: Neuroscience News]NEUROSCIENCE NEWSJULY 27, 2017 FEATUREDNEUROSCIENCEOPEN NEUROSCIENCE ARTICLES8 MIN READ *Summary: Researchers report becoming consciously aware of a decision conforms to the same mechanism the brain goes through to complete a simple decision.* *Source: Zuckerman Institute.* *Study in human participants lends insight into one of neuroscience’s greatest puzzles: How the brain transforms unconscious information into conscious thought.* Columbia scientists have identified th...mais »

Human Development Report 2016

Aloyzio AchuttiemAMICOR - Há 2 dias

Human Development Report 2016: Human Development for Everyone The 2016 Human Development Report is the latest in the series of global Human Development Reports published by the United Nations Development Programme (UNDP) since 1990 as independent, analytically and empirically grounded discussions of major development issues, trends and policies. Additional resources related to the 2016 Human Development Report can be found online at http://hdr.undp.org, including digital versions of the Report and translations of the overview in more than 20 languages, an interactive web version of t... mais »

Dia dos Avós

Aloyzio AchuttiemAMICOR - Há 3 dias

Dizem que 26 de julho é o dia dos avós. Temos quatro que estão nesta foto feita no dia 13 de junho p.p. aniversário da Valderês. Dois deles o Eduardo e o Pedro Martin, os dois da esquerda para direita devem viajar no início do próximo mês: Eduardo (camisa verde claro) vai para a Itália, de onde vieram vários de nossos ascendentes. O Pedro (blusa escura, logo atrás da Celita) vai para Santa Maria, de onde vim eu. Os outros dois Antônio e Júlia, permanecem por aqui para nos consolar, ao menos por enquanto. * Eduardo Pedro Martin Ant... mais »

chronic traumatic encephalopathy

Aloyzio AchuttiemAMICOR - Há 3 dias

High Prevalence of Evidence of CTE in Brains of Deceased Football Playersby Neuroscience News A new JAMA study reveals chronic traumatic encephalopathy was present in a exceptionally high number of brains of former football players. Researchers looked at the brains of former high school, college and NFL football players. Of the 202 brains analyzed, 177 showed signs of CTE. 110 of the 111 former NFL players brains were diagnosed with CTE. Researchers say that, while the findings are significant, the findings could have limitations due to the players families being motivated to donate... mais »

25 julho 1824 - início da Imigração Alemã

Aloyzio AchuttiemAMICOR - Há 4 dias

Imigração alemã-193 anos José Antonio Brenner Dia do Imigrante - Em 25.7.1824, os 1ºs imigrantes alemães chegaram à Colônia Alemã de São Leopoldo, então uma extensa área rural que passou a se desenvolver rapidamente. Eram 38 pessoas - homens, mulheres e crianças - que foram os pioneiros da imigração e colonização alemã no RGS. Ernst Zeuner (1895-1967) imaginou, em sua pintura, esse momento. Seguiram-se sucessivas levas que, com seus descendentes, muito contribuíram para o desenvolvimento e composição da identidade cultural de nosso Estado. Rendo homenagem aos meus ancestrais, cit... mais »