caffeine

Post-study caffeine administration enhances memory consolidation in humans

• Daniel Borota,
• Elizabeth Murray,
• Gizem Keceli,
• Allen Chang,
• Joseph M Watabe,
• Maria Ly,
• John P Toscano
• & Michael A Yassa

• Affiliations
• Contributions
• Corresponding author

Nature Neuroscience

 

(2014)

 

doi:10.1038/nn.3623

Received

 

30 October 2013 

Accepted

 

09 December 2013 

Published online

 

12 January 2014

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It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.

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