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Saturday, August 15, 2015

Pax6

How to create a genius mouse
August 10, 2015

The left brain hemisphere shows the normal level and cellular distribution of Pax6 expression in the developing neocortex. The right brain hemisphere shows a sustained, primate-like Pax6 expression pattern in the neocortex of a double transgenic mouse embryo. These animals have more Pax6-positive progenitor cells and a higher Pax6 expression level in the germinal layer close to the ventricle in the right hemisphere. (credit: © MPI of Molecular Cell Biology & Genetics) 
Scientists find a single gene can create primate-level neural development in the mouse neocortex
Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics have created a transgenic mouse in which a gene called Pax6, during embryonic development, is highly expressed in a specific group of brain cortical cells called neural progenitor stem cells (the cells that generate all cells that make up the brain). The resulting mouse … more…

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