Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years
J Am Coll Cardiol. 2016;67(9):1013-1022.
A very important unanswered question is whether 0 or very low CAC scores or other measures of lower extent of atherosclerosis or arteriosclerosis are associated with reduced risk of incident dementia. Interventions to modify known risk factors to prevent the progression of atherosclerosis and arteriosclerosis could result in a decreased older-age incidence of CHD, CVD, and dementia. The alternative could be an unfortunate outcome: that successful control of risk factors and treatment of CHD results in an increasing epidemic of dementia among older people.