Genoma

Nongenetic functions of the genome

1. Michael Bustin, 
2. Tom Misteli

+ Author Affiliations

1. Email: mistelit@mail.nih.gov (T.M.); bustinm@mail.nih.gov (M.B.)

Science  06 May 2016:
Vol. 352, Issue 6286,
DOI: 10.1126/science.aad6933

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The nongenetic roles of the nucleus

The eukaryotic cell nucleus provides a home for the genetic material and accessory proteins. As a physical entity, the nucleus also plays an important role in cell dynamics. Bustin and Misteli Review the impacts that the nucleus can have as a nongenetic force. For example, compacted DNA and the nuclear membrane affect nuclear morphology, the cellular response to mechanical force, cell migration, and cell signaling. Chromatin is not only affected by physical forces in cells but participates in a crosstalk of signaling inside cells.

Science, this issue p. 10.1126/science.aad6933