Opening the blood-brain barrier allows the body to remove plaque in the hippocampus
February 20, 2015
For the first time, researchers have reversed some of the symptoms of Alzheimer’s disease* in mice using magnetic resonance (MR) imaging-guided focused ultrasound.
As KurzweilAI reported in 2012, Sunnybrook Research Institute scientists used MR imaging-guided focused ultrasound to temporarily open the blood-brain barrier (BBB), allowing for more effective delivery of drugs to the brain. The method uses a microbubble contrast agent. The microbubbles vibrate when they pass through the ultrasound beam, temporarily creating an opening in the BBB for the drugs to pass through. In addition, this combination of ultrasound and microbubbles has been shown to increase the number of new neurons and the dendrite length.