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Several interventions have been identified that significantly extend healthy lifespan in mammals. Caloric restriction, for example, has been shown to improve healthspan in a variety of organisms, including rodents. Conversely, animals fed a diet with a normal caloric content, but with limiting amounts of the essential amino acid methionine, are up to 45% longer-lived than control animals. These and many other studies collectively demonstrate that alterations in nutrition and metabolism can have profound effects on healthy aging.
While studies are ongoing using conventional and established approaches to explore the molecular mechanisms underlying healthspan-extending interventions, many powerful new techniques are also being developed (e.g. genome engineering, high-throughput sequencing, DNA methylomics) that can be used to great effect for studies of healthy aging.
To explore the interplay between aging, nutrition, and metabolism, as well as the important role that novel technologies will play in current and future studies, The Orentreich Foundation for the Advancement of Science, Inc. and The Sackler Institute for Nutrition Science at the New York Academy of Sciences are bringing together several preeminent researchers in these fields.
Alzheimer's Disease as a Neurovascular Inflammatory Disorder
Tuesday, December 6, 2016 | 9:00 AM - 5:00 PM The New York Academy of Sciences
Growing evidence supports a role for neurovascular inflammation as a major factor in Alzheimer's Disease (AD) onset and progression. However, the scientific community has yet to label AD a vascular disease and questions remain about the viability of neurovascular inflammation as a potential therapeutic target. This symposium will evaluate clinical and preclinical data, and discuss critical barriers to understanding how to clinically test vascular-based hypotheses for the treatment of AD.