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Thursday, November 17, 2016

BAG3

BAG3 protein plays critical role in protecting heart from reperfusion injury, Temple research shows

(Philadelphia, PA) – The inability of cells to eliminate damaged proteins and organelles following the blockage of a coronary artery and its subsequent re-opening with angioplasty or medications – a sequence known as ischemia/reperfusion – often results in irreparable damage to the heart muscle. To date, attempts to prevent this damage in humans have been unsuccessful. According to a new study by scientists at the Lewis Katz School of Medicine at Temple University (LKSOM), however, it may be possible to substantially limit reperfusion injury by increasing the expression of a protein known as Bcl-2-associated athanogene 3 (BAG3)./.../

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