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Prospective epidemiologic studies have identified several risk factors for heart disease, and most can be the target of risk reduction interventions. The most widely recognized risk factors for atherosclerotic cardiovascular disease (ASCVD) include age, gender, cigarette smoking, sedentary lifestyle, elevated LDL, reduced HDL, hypertension, and diabetes. The consistency of associations between these factors and ASCVD risk across populations is substantial. Our understanding of the pathogenesis and etiology of coronary ASCVD, as well as its clinical implications, has grown tremendously over the past 20 y. The role garlic might play in treating ASCVD has been postulated for many years, but until recently no studies on garlic's ability to inhibit the atherosclerotic process have been reported. A pilot study evaluating coronary artery calcification and the effect of garlic therapy in a group of patients who were also on statin therapy suggested incremental benefits. The implications of this study must be put in context of the potential importance of early atherosclerosis detection and prevention./.../
Sponsored Supplement Publication Manuscript
Gordon M Lowe,
and Sarah Smith
Aged Garlic Extract Inhibits Human Platelet Aggregation by Altering Intracellular Signaling and Platelet Shape ChangeJ. Nutr. jn202408; first published online January 13, 2016.doi:10.3945/jn.114.202408
....M, Sarah Smith , G Lowe, Gordon Lowe, K Rahman, Rahman, Khalid, Lowe, Gordon M, Gordon M Lowe ] [Liverpool John Moores University, Liverpool, School of Pharmacy and Biomolecular Sciences, United Kingdom] AgedGarlicExtract Inhibits Human Platelet Aggregation by Altering Intracellular Signaling...
Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E–Knockout MiceJ. Nutr. jn206953; first published online January 13, 2016.doi:10.3945/jn.114.206953
...GarlicExtract Suppresses the Development of Atherosclerosis in Apolipoprotein E–Knockout Mice123  [T helper cell 1, agedgarlicextract, apolipoprotein E–knockout mice, triglyceride, atherosclerosis, CD11b, cholesterol] AgedGarlicExtract Suppresses the Development of Atherosclerosis...
Garlic-Derived Organic Polysulfides and Myocardial ProtectionJ. Nutr. jn208066; first published online January 13, 2016.doi:10.3945/jn.114.208066
...of the whole garlic clove in organic solvents. Although allicin is not contained in the extracted oil fragment, both DADS and DATS are readily available (14). Agedgarlicextract. Agedgarlicextract (AGE) is prepared by storing raw sliced garlic in 15–20% ethanol for 20mo in a stainless steel tank...
Development of an Analytic Method for Sulfur Compounds in Aged Garlic Extract with the Use of a Postcolumn High Performance Liquid Chromatography Method with Sulfur-Specific DetectionJ. Nutr. jn208520; first published online January 13, 2016.doi:10.3945/jn.114.208520
...Pharmaceutical Co., Drug Discovery Laboratory, Akitakata, Ltd., Japan] Development of an Analytic Method for Sulfur Compounds in AgedGarlicExtract with the Use of a Postcolumn High Performance Liquid Chromatography Method with Sulfur-Specific Detection123  [hexaiodoplatinate reagent, agedgarlicextract...
Pharmacokinetics of S-Allyl-L-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal ReabsorptionJ. Nutr. jn201749; first published online January 13, 2016.doi:10.3945/jn.114.201749
...Hirotaka, Kenji Itoh , Kenji Itoh] [Wakunaga Pharmaceutical Co., Drug Discovery Laboratory, Akitakata, Ltd., Japan] Pharmacokinetics of S-Allyl-l-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal Reabsorption12  [agedgarlicextract, renal reabsorption, oral absorption...