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Saturday, January 10, 2015

Antibiotic resistance

Finally, an antibiotic that kills pathogens like MRSA without resistance

January 9, 2015
The iChip houses growing microorganisms, using semi-permeable membranes (shown as circles) on each side of the plate. After adding agar nutrient, it is placed in the soil from which the sample originated. (Credit: Losee L. Ling et al./Nature)
North­eastern University researchers have dis­cov­ered an antibi­otic called “teixobactin” that elim­i­nates pathogens without encoun­tering any detectable resistance — a finding that chal­lenges long-held sci­en­tific beliefs and holds great promise for treating chronic infec­tions like tuber­cu­losis and those caused by MRSA.
Pathogens’ resis­tance to antibi­otics is causing a public health crisis, according to Northwest’s Uni­ver­sity Dis­tin­guished Pro­fessor Kim Lewis.
Lewis’ lab played a key role in ana­lyzing and testing teixobactin for resis­tance from pathogens. Lewis said this marks the first dis­covery of an antibi­otic to which resis­tance by muta­tions of pathogens have not been identified.
The research was published Wednesday Jan. 7 in the journal Nature. Lewis and North­eastern biology pro­fessor Slava Epstein co-authored the paper with col­leagues from the Uni­ver­sity of Bonn in Ger­many, Novo­Bi­otic Phar­ma­ceu­ti­cals in Cam­bridge, Mass­a­chu­setts, and Selcia Lim­ited in the United Kingdom./.../

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