NEW YORK (Reuters Health) - Lifetime-acquired loss of Y chromosome (LOY) in blood in men may increase the risk of Alzheimer's disease (AD) and may explain why men live shorter lives than women on average, according to new research.
Dr. Jan P. Dumanski of Uppsala University in Sweden and colleagues analyzed data from three independent studies of dementia: two prospective studies and one case-control study. All participants were genotyped, and the researchers used a continuous variable, the median of the log R ratio (mLRRY), to estimate the degree of LOY in each participant.
Of more than 3,200 participants included in their analysis, the researchers found detectable LOY in 546 (17%), with an mLRRY value lower than the 99% confidence limit. The frequency of LOY was similar in all three studies, 17.5%, 21.1%, and 15.4%/.../