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Summary: Findings could lead to new drug targets for pain management.
Source: Indiana University.
Genes identified as affecting nerve sensitivity in fruit flies could represent future drug targets in human pain management.
Indiana University researchers have that found a suite of genes in both fruit flies and humans — including one dubbed “smoke alarm” — plays a role in nerve sensitivity. The study could help lead to new drug targets in pain management.
The research, published today in the journal Cell Reports, was led by W. Daniel Tracey Jr., a professor in the IU Bloomington College of Arts and Sciences’ Linda and Jack Gill Center for Biomolecular Science and the Department of Biology.
“Our study is the first to thoroughly assess the function of a large set of genes expressed at high levels in nociceptive neurons, the nerves responsible for the sensation of pain in humans,” Tracey said. “It represents a significant step forward in the field of nociception and pain research.”/.../