Cancer risk linked to DNA ‘wormholes’
February 25, 2015

The researchers found that DNA sequences within “gene deserts” — so called because they are completely devoid of genes — can regulate gene activity elsewhere by forming DNA loops across relatively large distances.
The study helps solve a mystery about how genetic variations in parts of the genome that don’t appear to be doing very much can increase cancer risk.
Their study, published in Nature Communications, also has implications for the study of other complex genetic diseases.