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Tuesday, November 07, 2017

Antibody-dependent enhancement

Scientists Solve a Dengue Mystery: Why Second Infection Is Worse than First

Antibodies from a first bout can raise the risk of more severe disease if the virus is contracted later

For decades there has been a counterintuitive and hotly debated theory about dengue infections: that antibodies generated by a previous bout of dengue could actually put a person at risk of more severe disease if they contracted the virus a second time.
And now American and Nicaraguan scientists have published evidence that may silence the skeptics. Antibody-dependent enhancement, or ADE as it’s known in scientific circles, can happen, they reported, when subsequent infection occurs at a time when antibodies generated by the prior infection have fallen to a specific low range./.../

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