3.093 - AMICOR (25)

 3.093 - AMICOR (25)

#Antônio Achutti Olivé com sua avó em Buenos Aires

Logo após sua apresentação como componente da OSPA, em BA no Teatro Colón

No dia 10/07/2022 a OSPA, com sucesso se apresentou pela primeira vez em 72 anos no Teatro Colón. Nosso neto Antônio, como percussionista da OSPA, fez parte da apresentação, que poderá ser vista através do link. Dra. Mabel Morón é também médica, e reside em BA. Pensando  na data da fundação da OSPA, lembrei-me que a 71 anos, eu conheci a outra avó dele - Dra. Valderês Antonietta Robinson Achutti - que infelizmente não assistiu o espetáculo porque faleceu no ano passado.

1:55:01TOCANDO AGORA

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OSPA 2022 - 10/07 - Teatro Colón convida OSPA | Rachmaninoff | Arthur Barbosa | Villa-Lobos - 2,7 mil visualizações Transmitido há 12 horas

#Slide show AMICOR com as fotos de abertura

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#MEDPAGEtoday

ADHD Drugs May Treat Alzheimer's Cognitive Symptoms Effectively

— Positive effect on global cognition, apathy in meta-analysis

by Judy George, Deputy Managing Editor, MedPage Today July 5, 2022

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Drugs with principally noradrenergic action -- including ones prescribed for attention deficit-hyperactivity disorder (ADHD) or to treat hypertension or depression -- may effectively treat cognitive symptoms and apathy in Alzheimer's disease, a systematic review and meta-analysis suggested./.../

#ECHOLOGY - From Maira Popova

In 1866, the young German marine biologist Ernst Haeckel — whose exquisite illustrations of single-celled underwater creatures had enchanted Darwin — gave that interdependence a name: He called it ecology, from the Greek oikos, or “house, and logia, or “the study of,” denoting the study of the relationship between organisms in the house of life.

#ASRM

#NASA

The Future Is Gazing Into the Deepest Reaches of the Known Universe's Unmatched Majesty. 12 JULY 2022

TOP STORY

NASA Officially Unveils First Set of Dazzling James Webb Images We have waited, and now, we've received: The full first set of images from NASA's James Webb Telescope are here. They show the resplendence of the deepest reaches of the universe we can see, in ways you've never seen them before. To look at this imagery is to look at history as it unfolds before us. READ MORE → #TWITTER/NASA Here are five things we learned while seeing those first images from the Webb space telescope Traduzir Tweet nytimes.com Five Things Learned From the Webb Telescope’s First Images There is a lot more universe out there to see than there was before the telescope launched, and there is so much more to explain.

#Mário Maranhão +

Recebi a triste notícia do falecimento hoje pela madrugada do eminente cardiologista, Dr. Mário Maranhão, em Curitiba, onde morava  e exercia a profissão. Teve intensa atividade associativa e científica, tendo sido Presidente da SBC e da Federação Mundial de Cardiologia (WHF) com sede em Genebra.

#NYTIMES

As Y Chromosomes Vanish With Age, Heart Risks May Grow A study of mice might explain why.

A scanning electron micrograph of human X and Y chromosomes. A new study suggests loss of the Y chromosome could explain men’s shorter life spans.Credit...Biophoto Associates/Science Source

#NATURE

A sequence-based global map of regulatory activity for deciphering human genetics

• Kathleen M. Chen, 
• Aaron K. Wong, 
• Olga G. Troyanskaya & 
• Jian Zhou

Nature Genetics volume  54, pages 940–949 (2022)

• details

Abstract

Epigenomic profiling has enabled large-scale identification of regulatory elements, yet we still lack a systematic mapping from any sequence or variant to regulatory activities. We address this challenge with Sei, a framework for integrating human genetics data with sequence information to discover the regulatory basis of traits and diseases. Sei learns a vocabulary of regulatory activities, called sequence classes, using a deep learning model that predicts 21,907 chromatin profiles across >1,300 cell lines and tissues. Sequence classes provide a global classification and quantification of sequence and variant effects based on diverse regulatory activities, such as cell type-specific enhancer functions. These predictions are supported by tissue-specific expression, expression quantitative trait loci and evolutionary constraint data. Furthermore, sequence classes enable characterization of the tissue-specific, regulatory architecture of complex traits and generate mechanistic hypotheses for individual regulatory pathogenic mutations. We provide Sei as a resource to elucidate the regulatory basis of human health and disease.

Fig. 5: Disease regulatory mutations are predicted to disrupt promoter, CTCF and tissue-specific enhancer sequence classes.

Sequence class-level mutation effects of pathogenic noncoding HGMD mutations were plotted. A polar coordinate system was used, where the radial coordinate indicates the sequence class-level effects. Each dot represents a mutation and mutations inside the circle are predicted to have positive effects (increased activity of sequence class); mutations outside the circle are predicted to have negative effects (decreased activity of sequence class). Dot size indicates the absolute value of the effect. Mutations were assigned to sequence classes based on their sequences and predicted effects (Methods). Within each sequence class, mutations were ordered by chromosomal coordinates. The associated disease and gene name were annotated for each mutation and only the strongest mutation was annotated if there were multiple mutations associated with the same disease, gene and sequence class.

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#The Marginalian - Maria Popova

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Hello Aloyzio Achutti! This is the midweek edition of The Marginalian (formerly Brain Pickings) by Maria Popova — one piece resurfaced from the fifteen-year archive as timeless uplift for heart, mind, and spirit. If you missed last week's archival resurrection — Mary Oliver on happiness, fear, and the sublime interconnectedness of life — you can catch up right here. And if my labor of love enriches your life in any way, please consider supporting it with a donation — it remains free and ad-free and alive thanks to reader patronage. If you already donate: I appreciate you more than you know. FROM THE ARCHIVE | Love, Kindness, and the Song of the Universe: The Night Jack Kerouac Kept a Young Woman from Taking Her Own Life In the late 1950s, a young woman named Lois Sorrells Beckwith did what many passionate book-lovers find themselves doing — she fell in love with an author through his work; not with the writing alone, but with the man. That man was Jack Kerouac and the book that tipped Lois over the edge of infatuation was his newly published novella The Subterraneans (public library), a semi-fictional account of a fervid romance. But then Lois did something few ardent readers would dare to do. A native New Englander then living in California, she moved back to the East Coast and, one fateful afternoon in 1958, mustered the timid brazenness to drive herself to Kerouac’s home in Northport, Long Island, hoping to meet him. She pulled up to the house and found him sitting under a tree in his front yard, meditating — a practice he had taken up some years earlier as he plunged into Buddhist philosophy./.../ #The Lancet PH ARTICLE Effect of comprehensive smoke-free legislation on neonatal mortality and infant mortality across 106 middle-income countries: a synthetic control study Open Access

#PsychCentral

NEW PODCAST EPISODE

When Does Nail Biting or Skin Picking Become a Medical Condition?

Hosted by Gabe Howard

When does a “bad habit” become a medical disorder? Join us as Luisa Zettinig explains her own history with body-focused repetitive behaviors (BFRBs), why she believes community can be a powerful tool for healing, and how her company aims to foster mindfulness for people who live with BFRBs.

SEE EPISODE # GENERAL RELATIVITY | ALL TOPICS   Mass and Angular Momentum, Left Ambiguous by Einstein, Finally Get Defined By STEVE NADIS Surprising as it may sound, 107 years after the introduction of general relativity, the meanings of basic concepts are still being worked out. Read the article COMBINATORICS   Hypergraphs Reveal Solution to 50-Year-Old Problem By LEILA SLOMAN In 1973, Paul Erdős asked if it was possible to assemble sets of “triples” — three points on a graph — so that they abide by two seemingly incompatible rules. A new proof shows it can always be done. Read the blog Related:  Mathematicians Settle Erdős Coloring Conjecture by Kelsey Houston-Edwards (2021) QUANTUM COMPUTING   Quantum Algorithms Conquer a New Kind of Challenge By MORDECHAI RORVIG Computer scientists have found a new type of problem that quantum computers can solve dramatically faster than their classical counterparts. Is it the first in a new frontier of computational accomplishments? Read the blog Related:  How Quantum Computers Will Correct Their Errors by Katie McCormick (2021) DEVELOPMENTAL BIOLOGY   Embryo Cells Set Patterns for Growth by Pushing and Pulling By MONIQUE BROUILLETTE Patterns that guide the development of feathers and other features can be set by mechanical forces in the embryo, not just by gradients of chemicals. Read the blog Related:  Ancient Turing Pattern Builds Feathers, Hair — and Now, Shark Skin by Jonathan Lambert (2019) THE JOY OF WHY   How Do Mathematicians Know Their Proofs Are Correct? Podcast hosted by STEVEN STROGATZ What does evidence look like in the realm of mathematical abstraction? Hear the mathematician Melanie Matchett Wood explain how probability helps to guide number theorists toward certainty. Listen to the podcast Read the transcript Around the Web Platonic Reasoning A new model of artificial intelligence called PLATO has taken a step closer to having common-sense knowledge of how objects behave. It does so by focusing on whole objects rather than pixels to learn about the laws of physics, reports Dana G. Smith for Scientific American. While human infants acquire this grasp on reality early in life, the inability to use knowledge about the world to form new inferences has plagued AI for more than 50 years. In 2020 John Pavlus reported for Quanta on a new approach making progress by blending logic and deep learning. Jumping From Horses to Dragons The marine creatures called sea dragons look fantastically different from their close relatives, the sea horses. Scientists combing through the their genomes may have found the reason why in sections of repeating DNA code called transposons, reports Kate Golembiewski for The New York Times. These “jumping genes” could have copied and pasted themselves into the spots where the sea dragons were missing key growth genes. In 2021, Max Kozlov reported for Quanta on how the fusion of jumping genes can have major impacts throughout genomes. Transposons are often lumped in with other non-coding regions of the genome as “junk DNA.” Most of that DNA is truly nonfunctional but some, like transposons, can evolve genomic significance, as Jake Buehler explained for Quanta in 2021.