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Wednesday, November 14, 2012

Vit D


Vitamin D Gene Changes May Drive Disease

Variations in the vitamin D receptor gene may influence the clinical effects of low vitamin D levels in some chronic diseases, researchers found.
Among patients with low serum 25-hydroxyvitamin D (25(OH)D) in a U.S.-based cohort, the presence of one risk allele at rs7968585 was associated with a 40% increased risk for potentially fatal composite clinical outcomes, including hip fracture, myocardial infarction, cancer, and death (hazard ratio 1.40, 95% CI 1.12 to 1.74) according to Gregory Levin, PhD, of the University of Washington in Seattle, and colleagues.
The presence of two risk alleles was linked with an 82% increased risk (HR 1.82, 95% CI 1.31 to 2.54), they said./.../

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