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Thursday, February 08, 2018

Asparagine

Food may influence cancer spread

AsparagusImage copyrightGETTY IMAGES
There is mounting evidence the food on your plate can alter cancer's growth and spread, say Cambridge scientists.
Animal research, published in the journal Nature, showed breast tumours struggled without the dietary nutrient asparagine.
It is found in the foodies' favourite asparagus, as well as poultry, seafood and many other foods.
In the future, scientists hope to take advantage of cancer's "culinary addictions" to improve treatment.
Asparagine is an amino acid - a building block of protein - and takes its name from asparagus.

Spread

The study, conducted at the Cancer Research UK Cambridge Institute, took place on mice with an aggressive form of breast cancer.
Normally they would die in a couple of weeks as the tumour spread throughout the body.
But when the mice were given a low-asparagine diet or drugs to block asparagine then the tumour struggled to spread.
"It was a really huge change, [the cancers] were very difficult to find," said Prof Greg Hannon.
Last year, the University of Glasgow showed cutting out the amino acids serine and glycine slowed the development of lymphoma and intestinal cancers.
Prof Hannon told the BBC: "We're seeing increasing evidence that specific cancers are addicted to specific components of our diet.
"In the future, by modifying a patient's diet or by using drugs that change the way that tumour cells can access these nutrients we hope to improve outcomes in therapy."

Cancer

An initial tumour is rarely deadly. It is when the cancer spreads throughout the body - or metastasises - that it can become fatal.
A cancerous cell must go through huge changes in order to spread - it must learn to break off the main tumour, survive in the bloodstream and thrive elsewhere in the body.
It is this process for which researchers think asparagine is necessary.
But fear not asparagus lovers, these findings still need to be confirmed in people and asparagine is hard to avoid in the diet anyway.
In the long run, scientists think patients would be put on special drinks that are nutritionally balanced, but lack asparagine.
Prof Charles Swanton, Cancer Research UK's chief clinician, said: "Interestingly, the drug L-asparaginase is used to treat acute lymphoblastic leukaemia, which is dependent on asparagine.
"It's possible that in future, this drug could be repurposed to help treat breast cancer patients."
Further trials are still necessary.
Baroness Delyth Morgan, the chief executive at Breast Cancer Now, said patients should not go on drastic diets on the back of this study.
She said: "We don't recommend patients totally exclude any specific food group from their diet without speaking to their doctors.
"We'd also encourage all patients to follow a healthy and varied diet."
Follow James on Twitter.

Curie & Langevin affair


The Langevin Affair

image
[***] // In 1903, the Royal Swedish Academy of Sciences awarded Pierre Curie, Marie Curie and Henri Becquerel the Nobel Prize in Physics, “in recognition of the extraordinary services they have rendered by their joint researches on the radiation phenomena discovered by Professor Henri Becquerel.” […] Eight years later, [Marie Curie] would receive the 1911 Nobel Prize in Chemistry […] A month after accepting her 1911 Nobel Prize, she was hospitalized with depression and a kidney ailment. SkÅ‚odowska–Curie was the first person to win or share two Nobel Prizes. [***]/.../
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Read the “Don’t Let the Bastards Get You Down” Letter That Albert Einstein Sent to Marie Curie During a Time of Personal Crisis (1911)

Wednesday, February 07, 2018

Twist on Medical Education

MEDICAL NEWS & PERSPECTIVES

Essential Medicines

Estimated costs of production and potential prices for the WHO Essential Medicines List

Andrew M HillMelissa J BarberDzintars Gotham

Abstract

Introduction There are persistent gaps in access to affordable medicines. The WHO Model List of Essential Medicines (EML) includes medicines considered necessary for functional health systems.
Methods A generic price estimation formula was developed by reviewing published analyses of cost of production for medicines and assuming manufacture in India, which included costs of formulation, packaging, taxation and a 10% profit margin. Data on per-kilogram prices of active pharmaceutical ingredient exported from India were retrieved from an online database. Estimated prices were compared with the lowest globally available prices for HIV/AIDS, tuberculosis (TB) and malaria medicines, and current prices in the UK, South Africa and India.
Results The estimation formula had good predictive accuracy for HIV/AIDS, TB and malaria medicines. Estimated generic prices ranged from US$0.01 to US$1.45 per unit, with most in the lower end of this range. Lowest available prices were greater than estimated generic prices for 214/277 (77%) comparable items in the UK, 142/212 (67%) in South Africa and 118/298 (40%) in India. Lowest available prices were more than three times above estimated generic price for 47% of cases compared in the UK and 22% in South Africa.
Conclusion A wide range of medicines in the EML can be profitably manufactured at very low cost. Most EML medicines are sold in the UK and South Africa at prices significantly higher than those estimated from production costs. Generic price estimation and international price comparisons could empower government price negotiations and support cost-effectiveness calculations.

US toxic spills at chemical sites.


Recomendado pela AMICOR Berenice Goelzer
Extreme weather linked to climate change has increased the frequency and severity of flooding, amplifying the risk of toxic spills at chemical sites.

https://www.nytimes.com/interactive/2018/02/06/climate/flood-toxic-chemicals.html

From The New York Times:

Floods Are Getting Worse, and 2,500 Chemical Sites Lie in the Water’s Path

Campo magnético cósmico

Veja a mais detalhada simulação do universo já criada

Por , em 6.02.2018
Nós provavelmente nunca vamos compreender plenamente o tamanho do nosso universo. Nós sabemos que ele é grande, mas é difícil para a mente humana mensurar algo infinitamente grande. Mas isso não quer dizer que nós não podemos tentar.
Uma equipe internacional de astrofísicos acabou de lançar, com o auxílio de avanços computacionais, o melhor modelo do universo já criado. O projeto é a simulação de escala universal com mais informações já produzida./.../

The level of accuracy being achieved so far is exciting. Already, three papers have been published describing the large scale clustering of matter, helping us understand how galaxies form.

Of course, anything found in the simulations are simply flags that require closer inspection by astronomers.

Astrophysicists Have Built The Most Detailed Simulation of The Universe Ever Created

1 billion light years in a supercomputer.
MIKE MCRAE
2 FEB 2018
Saying our Universe is a big place is a bit of an understatement. And with recent advances in our understanding of the effects of dark matter and black holes on the formation of galaxies, it's surprisingly dynamic.

Médicas Gaúchas

Saiu na ZH de ontem.
Lembrei-me de minha Dra. Valderês, homenageada pelo SIMERS profissionais do RS (veja abaixo)

http://www.muhm.org.br/index.php?formulario=mulheres&metodo=4&id=0&submenu=2

PROTAGONISMO HISTÓRICO


Na ZH de hoje de meu companheiro de hidroginástica

Antonio Domingos Padula: reformas e poder

Professor titular na Escola de Administração da Universidade Federal
 do Rio Grande do Sul (UFRGS)


Entre semelhanças e diferenças que países como China e Alemanha têm com países jovens como o Brasil, uma chama a atenção atualmente: governantes que tentaram ou implementaram reformas sociais não conseguiram se manter no poder. Em 1898, o imperador chinês Guangxu editou 40 decretos visando modernizar o Estado, sua administração, economia e o sistema político. Não conseguiu implantar as reformas  porque as classes dominantes da época se sentiram ameaçadas e o resultado é conhecido. Em 1911, emergiu a revolução que implantou a República e o imperador perdeu seu trono. Entre 1998 e 2005, o chanceler Gerhard Schröder, diante da perda de competitividade da Alemanha, aprovou uma série de reformas sociais (permissão de trabalho temporário e parcial, redução de barreiras à contratação e à demissão, restrições às aposentadorias precoces e facilitação nas negociações entre patrões e empregados). 

Deputados federais e estaduais, assumam o protagonismo histórico e votem as reformas

ANTONIO DOMINGOS PADULA

Nas eleições de 2005, as forças contrárias a essa modernização venceram as eleições e o chanceler perdeu o cargo. Como resultados dessas reformas, hoje a Alemanha é o terceiro maior exportador mundial e com taxa de desemprego abaixo de 4%. No Brasil, entre 2015 e 2017, o governo aprovou no Congresso algumas reformas sociais com possibilidades de transformações (restrição da expansão da dívida pública, reforma trabalhista, regulamentação do trabalho temporário e terceirização, taxas de juros do BNDES). Falta ainda a reforma da Previdência para que esta seja justa (elimine privilégios e benesses concedidas aos agentes dos poderes Judiciário, Legislativo e certos setores do Executivo) e sustentável (benefício compatível com a contribuição).
As forças políticas e sociais, principalmente as populistas e aquelas que perderiam privilégios, já revelam sua potência. Os resultados de pesquisas eleitorais sinalizam que, como na China e na Alemanha, este governo reformista está com seus dias contados. Mas parece que nossas possibilidades não estão esgotadas. Para os(as) deputados(as), este mesmo fenômeno não é tão direto. Estando, individualmente, menos expostos que os agentes do Poder Executivo, os(as) deputados(as) correm menor risco de perder o mandato nas eleições de 2018. Assim, deputados(as) federais e estaduais, assumam o protagonismo histórico e votem as reformas cujas necessidades estão aí reveladas (Previdência e lei de recuperação fiscal do RS). Com as reformas, haverá recursos para investimento em segurança, educação, saúde e infraestrutura. Os jovens agradecerão.

Tuesday, February 06, 2018

Serotonin receptor structure

Full Length Serotonin Receptor Structure Seen For First Time

by Neuroscience News

Image shows a stick model of serotonin.
The newly revealed structure sets the stage for determining structures of the receptor in the active and drug-bound forms. NeuroscienceNews.com image is in the public domain.
Summary: Researchers have been able to view the full length of serotonin receptors for the first time, with the help of Nobel prize winning microscope technology. The snapshot of the receptor includes details of molecular binding sites that could help with the development of a range of new drugs.
Source: Case Western Reserve University.
A team of researchers from Case Western Reserve University School of Medicine have used Nobel prize-winning microscope technology to see full length serotonin receptors for the first time. The tiny proteins–approximately a billionth of a meter long–are common drug targets, despite limited available information about their structure. Now, new images published in Nature Communications provide snapshots of the receptors, including details about molecular binding sites that could lead to more precise drug design
Serotonin receptors sit in cell membranes throughout the body, including the brain, stomach, and nerves. They are highly dynamic with many moving parts, making them difficult subjects to capture. Researchers commonly break the receptor into pieces to study it. But by studying full-length serotonin receptors, researchers in the new study showed how its different portions interact. The researchers describe “a finely tuned orchestration of three domain movements” that allows the receptors to elegantly control passageways across cell membranes./.../

Teeth's Regeneration

Instead of Filling Cavities, Dentists May Soon Regenerate Teeth

For dentists, a cavity is a conundrum—in order to save the tooth they must further damage it. Currently, the primary way to treat a cavity is to excavate the decay and the surrounding area before filling the resulting crater with a durable surrogate material such as metal, plastic or glass cement./.../