Effect of Intensive vs Standard Blood Pressure Control on Probable DementiaA Randomized Clinical Trial
The SPRINT MIND Investigators for the SPRINT Research Group
JAMA. 2019;321(6):553-561. doi:10.1001/jama.2018.21442
Question Does intensive blood pressure control reduce the occurrence of dementia?
Findings In this randomized clinical trial that included 9361 adults with hypertension, randomization to a systolic blood pressure target of less than 120 mm Hg compared with less than 140 mm Hg resulted in a rate of probable dementia of 7.2 vs 8.6 cases per 1000 person-years, a difference that was not statistically significant.
Meaning Among adults with hypertension, intensive blood pressure control did not significantly reduce the risk of probable dementia.
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