December 21, 2011 — Phosphorylated alpha-synuclein, which may be detected in blood plasma, shows promise as a diagnostic biomarker for Parkinson's disease (PD), researchers report in the December issue of the Journal of the Federation of American Societies for Experimental Biology (the FASEB Journal).
Alpha-synuclein is believed to play a "pivotal role" role in the development of the synucleinopathies, PD, and dementia with Lewy bodies (DLB), Penelope G. Foulds, PhD, from the University of Lancaster, United Kingdom, and colleagues note in their report.
The fact that this protein is present in human body fluids, including cerebrospinal fluid (CSF) and blood plasma, has fueled interest in its use as a biomarker for PD. However, most studies to date have relied on immunoassays that do not distinguish between monomeric/oligomeric and nonphosphorylated/phosphorylated forms of the protein, the researchers say/.../
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