Gene Study Yields Possible New Alzheimer's Target
![Human macrophages stained with TREM2 (red) and MS4A4A (green). [Credit: Fabia Filipello and Dennis Oakley]](https://clf1.medpagetoday.com/media/images/81xxx/81603.jpg)
A mechanistic explanation of how two genes may influence Alzheimer's disease risk has been identified, researchers reported.
The genes, known as MS4A4 (membrane-spanning 4-domains subfamily A) and TREM2 (triggering receptor expressed on myeloid cells 2), operate in the microglia and appeared to influence Alzheimer's risk by altering levels of TREM2, a protein that may help microglia cells clear excessive amounts of brain amyloid and tau, reported Carlos Cruchaga, PhD, Celeste Karch, PhD, and Laura Piccio, MD, PhD, of Washington University School of Medicine in St. Louis, and colleagues, in Science Translational Medicine.
No comments:
Post a Comment