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Sunday, February 19, 2012

2537 - AMICOR 14


The Health Promotion Clearinghouse

Aloyzio AchuttiemAMICOR - 2 minutos atrás
*The Health Promotion Clearinghouse* *Overview * *Why Take a Population Health Approach? * A population health approach focuses on improving the health status of the population. Action is directed at the health of an entire population, or sub-population, rather than individuals. Focusing on the health of populations also necessitates the reduction in inequalities in health status between population groups. An underlying assumption of a population health approach is that reductions in health inequities require reductions in material and social inequities. The outcomes or benefits o... mais »

End-of-Life Care Planning

Aloyzio AchuttiemAMICOR - 1 dia atrás
*End-of-Life Care Planning: *Research shows that the medical care elderly receive at the end-of-life is often different from what they would choose, and most elderly say they would prefer to die at home rather than in hospitals and nursing homes as most now do. More than one in four elderly Americans are incapacitated at the end of their lives and unable to make their own medical care decisions, according to the first large-scale study of advance directives based on the deaths of HRS participants. The researchers found that the overwhelming majority of older adults who died with ad... mais »

storage in the cloud

Aloyzio AchuttiemAMICOR - 1 dia atrás
Infinite storage in the cloudFebruary 14, 2012 by Amara D. Angelica Bitcasa has created a new cloud service that promises “infinite storage” in the cloud for Windows and Mac. Once you install Bitcasa it prompts you to choose which of your folders to “cloudify.” Cloudified folders are uploaded to Bitcasa’s cloud right away and get a Bitcasa logo added to the system tray or Finder. Any time you save, copy, or paste new files into a cloudified folder they also uploaded. You’ll also be able to access your files from any device, wherever you are, the company says. It’s not available public... mais »

human antiviral system

Aloyzio AchuttiemAMICOR - 1 dia atrás
*Na mesma direção aportada pela AMICOR Maria Inês Reinert Azambuja, juntando virus, atheroesclerose, inflamação e sistema imunitário...*Cell death unleashes full force of human antiviral systemFebruary 13, 2012 A scientific team led by researchers at the University of Geneva (UNIGE) and the Charité Berlin Medical University has discove showing how much our immune system is provoked into action when confronted by viral intruders. The possibility of exploiting this mechanism in vaccines holds promise for the development of new ways of preventing and treating infectious diseases and can... mais »

Google’s page-rank software

Aloyzio AchuttiemAMICOR - 2 dias atrás
Applying Google’s page-rank software to the molecular worldFebruary 15, 2012 [image: Page Rank] Google's PageRank software has been adapted to determine the way molecules are shaped, organized, and combined (credit: WSU) Aurora Clark, an associate professor of chemistry at Washington State University, has adapted Google’s PageRank software to create molecular networks that scientists can use to determine molecular shapes and chemical reactions without the expense, logistics, and occasional danger of lab experiments. The software focuses on hydrogen bonds in water, earth’s most abundan... mais »

breast cancer

Aloyzio AchuttiemAMICOR - 2 dias atrás
Radiation treatment transforms breast cancer cells into cancer stem cellsFebruary 15, 2012 The molecular pathways that maintain "stem-ness" in stem cells are also active in numerous cancers. This similarity has led scientists to propose that cancers may arise when some event produces a mutation in a stem cell, robbing it of the ability to regulate cell division. This figure illustrates 3 hypotheses of how a cancer stem cell may arise: (1) A stem cell undergoes a mutation, (2) A progenitor cell undergoes two or more mutations, or (3) A fully differentiated cell undergoes several muta... mais »

‘suicide’ messages to cancer cells

Aloyzio AchuttiemAMICOR - 2 dias atrás
DNA nanorobots deliver ‘suicide’ messages to cancer cells, other diseasesFebruary 17, 2012 *[+]*[image: gatednanorobot1c] Hinged nanorobot opens when target molecules are sensed Researchers at Harvard University’s Wyss Institute for Biologically Inspired Engineering have developed a nanorobotic device made from DNA that could potentially seek out specific cell targets within a complex mixture of cell types and deliver important molecular instructions, such as telling cancer cells to self-destruct. Inspired by the mechanics of the body’s own immune system, the technology might one day... mais »

Dementia, Stroke risk test

Aloyzio AchuttiemAMICOR - 2 dias atrás
Simple Tests May Flag Dementia, Stroke Risk By Charles Bankhead, Staff Writer, MedPage Today Published: February 15, 2012 Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner * * Action Points - Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal. - Explain that walking speed and hand-grip strength during middle age corr... mais »

understand online conversations

Aloyzio AchuttiemAMICOR - 3 dias atrás
Can computers understand online conversations? New software being developed at Oxford University may be able to instantly measure the emotions and reactions of large populations by evaluating the words we use on the internet. Investors seem to think this idea will pay off. So, why do we care? Well, this software, called TheySay, uses something called corpora linguistics, which basically means... Read more ››

Patients and Doctors

Aloyzio AchuttiemAMICOR - 3 dias atrás
Perspective 200th Anniversary Article Patients and Doctors — The Evolution of a Relationship Robert D. Truog, M.D. N Engl J Med 2012; 366:581-585February 16, 2012 Comments open through December 31, 2012 ArticleReferencesComments Audio Interview [image: Interview with Robert Truog on issues in medical ethics and the physician-patient relationship.] Interview with Robert Truog on issues in medical ethics and the physician-patient relationship. (21:39) - Listen - Download The relationship between patients and doctors is at the core of medical ethics, serving as an anchor for many ... mais »

Diagnosis of Alzheimer Disease Dementia

Aloyzio AchuttiemAMICOR - 5 dias atrás
*Revised Criteria for Mild Cognitive Impairment May Compromise the Diagnosis of Alzheimer Disease Dementia* John C. Morris, MD *Arch Neurol.* Published online February 6, 2012. doi:10.1001/archneurol.2011.3152 *ABSTRACT* ------------------------------ *Objective * To evaluate the potential impact of revised criteria for mild cognitive impairment (MCI), developed by a work group sponsored by the National Institute on Aging and the Alzheimer's Association, on the diagnosis of very mild and mild Alzheimer disease (AD) dementia.*Design * Retrospective review of ratings of functional imp... mais »

Population Health

Aloyzio AchuttiemAMICOR - 6 dias atrás
Conceptualising population health: The mechanistic interpretation of reality can be traced to the influential work by René Descartes and Sir Isaac Newton. Their theories were able to accurately predict most physical phenomena relating to motion, optics and gravity. This paradigm had at least three principles and approaches: reductionism, linearity and hierarchy. These ideas appear to have influenced social scientists and the discourse on population health. In contrast, Complexity Science takes a more holistic view of systems. It views natural systems as being 'open', with fuzzy bor... mais »

Benfluorex

Aloyzio AchuttiemAMICOR - 6 dias atrás
Over 1300 deaths in Mediator scandal in FranceFEBRUARY 9, 2012 Lisa Nainggolan *Villejuif**, France* - The number of deaths attributable to heart-valve insufficiency as a result of the use of *benfluorex*(Mediator, Servier) in France is much greater than previously thought, say two French researchers [*1*]. They estimate that 3100 people were hospitalized and over 1300 died due to valvular insufficiency associated with benfluorex use in the country during the period from 1976 to 2009. And these figures are likely underestimates, say *Drs Agnes Fournier* (INSERM,... mais »

Big Data

Aloyzio AchuttiemAMICOR - 1 semana atrás
The Age of Big DataBy STEVE LOHRPublished: February 11, 2012 Enlarge This Image GOOD with numbers? Fascinated by data? The sound you hear is opportunity knocking. Chad Hagen * * Mo Zhou was snapped up by I.B.M. last summer, as a freshly minted Yale M.B.A., to join the technology company’s fast-growing ranks of data consultants. They help businesses make sense of an explosion of data — Web traffic and social network comments, as well as software and sensors that monitor shipments, suppliers and customers — to guide decisions, trim costs and lift sales. “I’ve always had a love of numb...mais »

The Health Promotion Clearinghouse



The Health Promotion Clearinghouse


Overview 
Why Take a Population Health Approach? 
A population health approach focuses on improving the health status of the population. Action is directed at the health of an entire population, or sub-population, rather than individuals. Focusing on the health of populations also necessitates the reduction in inequalities in health status between population groups. An underlying assumption of a population health approach is that reductions in health inequities require reductions in material and social inequities. The outcomes or benefits of a population health approach, therefore, extend beyond improved population health outcomes to include a sustainable and integrated health system, increased national growth and productivity, and strengthened social cohesion and citizen engagement.

What You Will Find In This Document: 
Within the “Health Promotion and  Population Health” resource list, you will find a variety of information from provincial,  national and international sources on the topic population health. This resource list is organized into five sections: Overview, Documents, Organizational Links, Other Tools and Resources, and Funding Opportunities. A brief description of each section is included below:

  • Overview provides a general description of the topics represented in this resource list. 
  • Documents is made up of toolkits and reports that are available online.
  • Organizational Links lists relevant provincial, national and international groups affiliated with population health. 
  • Other Tools and Resources includes key websites, databases, and portals related to population health. 
  • Funding Opportunities is a list of organizations that provide financial assistance to organizations promoting health across the population. /.../

Saturday, February 18, 2012

End-of-Life Care Planning


End-of-Life Care Planning: Research shows that the medical care elderly receive at the end-of-life is often different from what they would choose, and most elderly say they would prefer to die at home rather than in hospitals and nursing homes as most now do. More than one in four elderly Americans are incapacitated at the end of their lives and unable to make their own medical care decisions, according to the first large-scale study of advance directives based on the deaths of HRS participants. The researchers found that the overwhelming majority of older adults who died with advance directives received the care they preferred. Those with a living will or durable power of attorney for health care (two-thirds of the total) were less likely to die in a hospital or to receive aggressive care, results that were consistent with their wishes.
Planning for end-of-life care is more effective when it is seen as an ongoing process of decisionmaking among patient, family members, and health care providers, rather than the creation of a legal document. Verbal information provided over multiple educational sessions is most likely to lead to end-of-life plans. Timing is important; educational interventions that targeted seriously ill patients are most successful. But researchers find that one-size-fits-all approaches to end-of-life care planning may exclude large numbers of patients in an increasingly ethnically diverse society, and point out that the challenge is to "design, test, and implement programs which accommodate a range of individual and cultural beliefs, values, and preferences."

Friday, February 17, 2012

storage in the cloud


Infinite storage in the cloud

February 14, 2012 by Amara D. Angelica
Bitcasa has created a new cloud service that promises “infinite storage” in the cloud for Windows and Mac.
Once you install Bitcasa it prompts you to choose which of your folders to “cloudify.” Cloudified folders are uploaded to Bitcasa’s cloud right away and get a Bitcasa logo added to the system tray or Finder.
Any time you save, copy, or paste new files into a cloudified folder they also uploaded. You’ll also be able to access your files from any device, wherever you are, the company says.
It’s not available publicly yet, but invites to a trial version of Bitcasa are circulating and you can sign up for a beta here. We will be testing it on a Mac and a PC this week. I found in the first test that it uploaded files to the cloud at a speed of about 10 MB/minute. Not too shabby.
Bitcasa will cost $10 a month with no storage cap for users, according to C|NET. (A free version will be “less than unlimited,” the company says.)/.../

human antiviral system


Na mesma direção aportada pela AMICOR Maria Inês Reinert Azambuja, juntando virus, atheroesclerose, inflamação e sistema imunitário...

Cell death unleashes full force of human antiviral system

February 13, 2012
A scientific team led by researchers at the University of Geneva (UNIGE) and the Charité Berlin Medical University has discove showing how much our immune system is provoked into action when confronted by viral intruders.
The possibility of exploiting this mechanism in vaccines holds promise for the development of new ways of preventing and treating infectious diseases and cancer.
Killer T cells (cytotoxic T lymphocytes) play a central role in our immune system. They are capable of specifically identifying and killing cells harbouring viruses or bacteria and also cancer cells. It is likely that cytotoxic T lymphocytes will play an important role in the future development of vaccines against HIV/AIDS, hepatitis C, malaria and also cancer.
It has long been known that viral infection in humans is followed by formation of an army of T lymphocytes. But how does this mobilization come about and who decides it? Researchers think that the alert is provided by dendritic cells capable of identifying a virus by its specific, characteristic molecular motifs called pathogen-associated molecular patterns or PAMPs. After identifying a pathogen, the dendritic cells then coordinate the action of cytotoxic T lymphocytes./.../

Applying Google’s page-rank software to the molecular world

February 15, 2012
Page Rank
Google's PageRank software has been adapted to determine the way molecules are shaped, organized, and combined (credit: WSU)
Aurora Clark, an associate professor of chemistry at Washington State University, has adapted Google’s PageRank software to create molecular networks that scientists can use to determine molecular shapes and chemical reactions without the expense, logistics, and occasional danger of lab experiments.
The software focuses on hydrogen bonds in water, earth’s most abundant solvent and a major player in most every biological process. In living things, water can perform key functions like helping proteins fold or organizing itself around the things it dissolves so molecules stay apart in a fluid state. But the processes are dazzlingly complex, changing in fractions of a second and in myriad possible forms.
Much like the trillion-plus Web domains on the Internet./.../

breast cancer


Radiation treatment transforms breast cancer cells into cancer stem cells

February 15, 2012
The molecular pathways that maintain "stem-ness" in stem cells are also active in numerous cancers. This similarity has led scientists to propose that cancers may arise when some event produces a mutation in a stem cell, robbing it of the ability to regulate cell division. This figure illustrates 3 hypotheses of how a cancer stem cell may arise: (1) A stem cell undergoes a mutation, (2) A progenitor cell undergoes two or more mutations, or (3) A fully differentiated cell undergoes several mutations that drive it back to a stem-like state. In all 3 scenarios, the resultant cancer stem cell has lost the ability to regulate its own cell division. (Credit: Terese Winslow/NIH)
Researchers with the UCLA Department of Radiation Oncology report that radiation treatment — despite killing half of all tumor cells during every treatment — transforms other cancer cells into treatment-resistant breast cancer stem cells.
The generation of these breast cancer stem cells counteracts the otherwise highly efficient radiation treatment. If scientists can uncover the mechanisms and prevent this transformation from occurring, radiation treatment for breast cancer could become even more effective, said study senior author Dr. Frank Pajonk, an associate professor of radiation oncology and Jonsson Cancer Center researcher./../

‘suicide’ messages to cancer cells


DNA nanorobots deliver ‘suicide’ messages to cancer cells, other diseases

February 17, 2012
[+]gatednanorobot1c
Hinged nanorobot opens when target molecules are sensed
Inspired by the mechanics of the body’s own immune system, the technology might one day be used to program immune responses to treat various diseases.
Using the DNA origami method  (complex 3-D shapes and objects are constructed by folding strands of DNA), the researchers created a nanosize robot in the form of an open barrel whose two halves are connected by a hinge./.../

Dementia, Stroke risk test


Simple Tests May Flag Dementia, Stroke Risk


NEW ORLEANS -- Walking speed and hand-grip strength during middle age correlated with cognitive function and stroke risk in older adults, suggesting simple tests might aid diagnosis of the two conditions, according to data from a large cohort study.
During 11 years of follow-up, slower walking speed at baseline was associated with a 50% rise in the hazard for dementia. Brain volume and performance on a variety of tests of cognitive function also were significantly lower in slower walkers./.../

Thursday, February 16, 2012

understand online conversations


Can computers understand online conversations?

New software being developed at Oxford University may be able to instantly measure the emotions and reactions of large populations by evaluating the words we use on the internet. Investors seem to think this idea will pay off. So, why do we care? Well, this software, called TheySay, uses something called corpora linguistics, which basically means...
Read more ››

Patients and Doctors


Perspective
200th Anniversary Article

Patients and Doctors — The Evolution of a Relationship

Robert D. Truog, M.D.
N Engl J Med 2012; 366:581-585February 16, 2012
 Comments open through December 31, 2012
Article
References
Comments
Audio Interview
Interview with Robert Truog on issues in medical ethics and the physician-patient relationship.
Interview with Robert Truog on issues in medical ethics and the physician-patient relationship. (21:39)
The relationship between patients and doctors is at the core of medical ethics, serving as an anchor for many of the most important debates in the field. Over the past several decades, this relationship has evolved along three interrelated axes — as it is defined in clinical care, research, and society. Many of the pivotal discussions of these issues have appeared in the pages of the Journal (see Key NEJM Articles on Medical Ethics).

CLINICAL CARE

The relationship between patients and doctors in the clinical realm has historically been framed in terms of benevolent paternalism. Until about 1960, most codes of medical ethics relied heavily on the Hippocratic tradition, framing the obligations of physicians solely in terms of promoting the welfare of the patient, while remaining silent about patients' rights. The past several decades have seen tectonic societal shifts that have resulted in increasing empowerment of individuals against the authority of government and institutions, creating a surge of rights-based movements, with patients' rights emerging as a societal demand alongside women's rights, minority groups' rights, consumers' rights, and others./.../

Tuesday, February 14, 2012

Diagnosis of Alzheimer Disease Dementia

Revised Criteria for Mild Cognitive Impairment May Compromise the Diagnosis of Alzheimer Disease Dementia
Arch Neurol. Published online February 6, 2012. doi:10.1001/archneurol.2011.3152
ABSTRACT


Objective  To evaluate the potential impact of revised criteria for mild cognitive impairment (MCI), developed by a work group sponsored by the National Institute on Aging and the Alzheimer's Association, on the diagnosis of very mild and mild Alzheimer disease (AD) dementia.Design  Retrospective review of ratings of functional impairment across diagnostic categories.
Setting  Alzheimer's Disease Centers and the National Alzheimer's Coordinating Center.
Participants  Individuals (N = 17 535) with normal cognition, MCI, or AD dementia.
Main Outcome Measures  The functional ratings of individuals with normal cognition, MCI, or AD dementia who were evaluated at Alzheimer's Disease Centers and submitted to the National Alzheimer's Coordinating Center were assessed in accordance with the definition of "functional independence" allowed by the revised criteria. Pairwise demographic differences between the 3 diagnostic groups were tested using t tests for continuous variables and {chi}2 for categorical variables.
Results  Almost all (99.8%) individuals currently diagnosed with very mild AD dementia and the large majority (92.7%) of those diagnosed with mild AD dementia could be reclassified as having MCI with the revised criteria, based on their level of impairment in the Clinical Dementia Rating domains for performance of instrumental activities of daily living in the community and at home. Large percentages of these individuals with AD dementia also meet the revised "functional independence" criterion for MCI as measured by the Functional Assessment Questionnaire.
Conclusions  The categorical distinction between MCI and milder stages of AD dementia has been compromised by the revised criteria. The resulting diagnostic overlap supports the premise that "MCI due to AD" represents the earliest symptomatic stage of AD./.../

Monday, February 13, 2012

Population Health


Conceptualising population health: 


The mechanistic interpretation of reality can be traced to the influential work by René Descartes and Sir Isaac Newton. Their theories were able to accurately predict most physical phenomena relating to motion, optics and gravity. This paradigm had at least three principles and approaches: reductionism, linearity and hierarchy. These ideas appear to have influenced social scientists and the discourse on population health. In contrast, Complexity Science takes a more holistic view of systems. It views natural systems as being 'open', with fuzzy borders, constantly adapting to cope with pressures from the environment. These are called Complex Adaptive Systems (CAS). The sub-systems within it lack stable hierarchies, and the roles of agency keep changing. The interactions with the environment and among sub-systems are non-linear interactions and lead to self-organisation and emergent properties. Theoretical frameworks such as epi+demos+cracy and the ecosocial approach to health have implicitly used some of these concepts of interacting dynamic sub-systems. Using Complexity Science we can view population health outcomes as an emergent property of CAS, which has numerous dynamic non-linear interactions among its interconnected sub-systems or agents. In order to appreciate these sub-systems and determinants, one should acquire a basic knowledge of diverse disciplines and interact with experts from different disciplines. Strategies to improve health should be multi-pronged, and take into account the diversity of actors, determinants and contexts. The dynamic nature of the system requires that the interventions are constantly monitored to provide early feedback to a flexible system that takes quick corrections./.../

Benfluorex


Over 1300 deaths in Mediator scandal in France

FEBRUARY 9, 2012 Lisa Nainggolan
    Villejuif, France - The number of deaths attributable to heart-valve insufficiency as a result of the use of benfluorex(Mediator, Servier) in France is much greater than previously thought, say two French researchers [1]. They estimate that 3100 people were hospitalized and over 1300 died due to valvular insufficiency associated with benfluorex use in the country during the period from 1976 to 2009.
And these figures are likely underestimates, say Drs Agnes Fournier (INSERM, Villejuif, France) and Mahmoud Zureik (INSERM Paris, France) in a report published online February 9, 2012 in Pharmacoepidemiology & Drug Safety.Prior guesses at the number of deaths associated with benfluorex have hovered around the 500 mark.
"Despite its similarity with the two appetite suppressants fenfluramine and dexfenfluramine, benfluorex was kept on the market for more than 30 years in France," say Fournier and Zureik. "Given the grave consequences benfluorex use has had for many people, a public investigation has been set in France to understand the reasons that have contributed to the delay in withdrawing benfluorex from the market and to stress needed reform of drug regulation."
This paper comes just a few days after investigators searched the offices of French healthcare regulator AFSSAPS(French Agency for Safety of Health Products), which is under scrutiny for allowing the sale of benfluorex in France long after it had been pulled from the market elsewhere, according to a Reuters report [2].

Benfluorex use was off-label for more than three decades in France
Benfluorex was marketed in France for more than 30 years, from 1976 to 2009, as an adjunct for the treatment of hyperlipidemia and among overweight patients with type 2 diabetes. Although it had anorexic properties, the drug was not marketed as an appetite suppressant, but it was used off-label for this purpose./.../

Sunday, February 12, 2012

Big Data


The Age of Big Data

GOOD with numbers? Fascinated by data? The sound you hear is opportunity knocking.
Chad Hagen

Mo Zhou was snapped up by I.B.M. last summer, as a freshly minted Yale M.B.A., to join the technology company’s fast-growing ranks of data consultants. They help businesses make sense of an explosion of data — Web traffic and social network comments, as well as software and sensors that monitor shipments, suppliers and customers — to guide decisions, trim costs and lift sales. “I’ve always had a love of numbers,” says Ms. Zhou, whose job as a data analyst suits her skills/.../
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