TOMM40 gene

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By Ana Sandoiu
Published Monday 18 September 2017The genetic narrative behind Alzheimer's disease may need to be adjusted, according to a new study.

So far, the consensus among scientists has been that the ApoE4 gene is the main marker of Alzheimer's disease and many other dementias. But new research adds another key player into the mix: the so-called TOMM40 gene.

The ApoE gene is instrumental in forming lipoproteins, which are molecules that carry cholesteroland other fats through our bloodstream.

ApoE has several slightly different versions, and one of them, called e4, has been strongly associated with the risk of developing Alzheimer's disease.

Moreover, the ApoE4 gene is linked to the buildup of amyloid plaque, which is a clumpy protein found in the brain tissue of Alzheimer's patients.