Microglia and Alzheimer's D.

Is “Friendly Fire” in the Brain Provoking Alzheimer's Disease?Scientists want to combat dementia and neurodegeneration by keeping the brain’s immune system from going rogue

Neuroscientist Michael Heneka knows that radical ideas require convincing data. In 2010, very few colleagues shared his belief that the brain’s immune system has a crucial role in dementia. So in May of that year, when a batch of new results provided the strongest evidence he had yet seen for his theory, he wanted to be excited, but instead felt nervous.
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Even so, the idea has sparked the interest of pharmaceutical investors, who see a large, and entirely unserved, market: an estimated 50 million people worldwide have dementia—a number the World Health Organization projects will rise to 82 million by 2030. Of the eight drug-discovery projects backed by Dementia Consortium—a UK-based group of charities and pharmaceutical companies that has poured £4.5 million (US$5.7 million) into the projects—four are aimed at inflammation./.../