June 8, 2020
JAMA. 2020;324(3):239-240. doi:10.1001/jama.2020.4085
Anew model of the pathogenesis of Alzheimer disease (AD) is challenging the old. New disease models do not always replace old models. Instead, the new sometimes completes the old.
The Old Model
Amyloid-β, Tau, and APOE
The pathogenesis of Alzheimer disease (AD) remained a mystery for 80 years. However, in recent decades, 3 molecules have been found to play crucial roles: amyloid-β (Aβ), found in plaques; tau, found in neurofibrillary tangles; and apolipoprotein E (APOE).1 Individuals who carry 2 copies of the allele for APOE*E4 are about 10 times more likely to develop the disease than those who have no copies of this allele./.../
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