Preventing Alzheimer's: Our lifespan has outpaced our brain's healthspan. Harvard professor of neurology Rudolph Tanzi has been at the leading edge of neuroscience as co-director of the Center for Brain Health at Mass General Hospital. His work illuminates the key role of neuroinflammation in Alzheimer's disease and the potential to stop it before symptoms emerge. Like cholesterol and heart disease, waiting for late-stage disease to initiate statin therapy is too late. Leveraging primary prevention and early detection modalities (i.e. imaging, polygenenic risk scores, to blood tests & eye-tracking modalities) and an early response will be key. In Dr. Tanzi's terrific talk at Exponential Medicine 2019, he explores the biology, new therapy approaches, including leveraging 3D brain organoid dish models, to developing an understanding and bring a future with personalized treatment, targeting the right pathology, with the right interventions at the right time. Dr. Tanzi closes with lessons on how to protect your brain, summarized by SHIELD (Sleep, Handling stress, Interaction with others, Exercise, Learning new things, and Diet).
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